A substrate-fusion protein is trapped inside the Type III Secretion System channel in Shigella flexneri.
The Type III Secretion System (T3SS) is a macromolecular complex used by Gram-negative bacteria to secrete effector proteins from the cytoplasm across the bacterial envelope in a single step.For many pathogens, the T3SS is an essential virulence factor that enables the bacteria to interact with and manipulate their respective host.A characteristic